Are you treating myocardial infarctions? Why? That's DEAD tissue! You should be treating myocardial ischemia! What's the difference between ST elevation and ST depression? Does ST depression ALWAYS represent a subendocardial ischemia? Does ST elevation ALWAYS represent an acute transmural ischemia? Which blood test do you use to confirm an acute transmural ischemia... ...troponins, or a CK-MB? If you base you diagnosis of an acute transmural ischemia on the presence of ST elevation according to the STEMI protocol, then you are basing your diagnosis on a CK-MB, because that's the test that was used to "prove" that the ST deviation was or was not a STEMI! The STEMI protocol was based on just ONE article that used CK-MB assays as proof of acute transmural ischemia. Is there a problem with that? Well, no... if you don't mind missing about 25% of acute transmural ischemias that should have gone directly to the cath lab but instead were...